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Quantification of left ventricular volumes and function in patients with cardiomyopathies by real-time three-dimensional echocardiography: a head-to-head comparison between two different semiautomated endocardial border detection algorithms.

Soliman OI, Krenning BJ, Geleijnse ML, Nemes A, Bosch JG, van Geuns RJ, Kirschbaum SW, Anwar AM, Galema TW, Vletter WB, ten Cate FJ

Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.

OBJECTIVE: We evaluated two different commercially available real-time 3-dimensional echocardiographic semiautomated border detection algorithms for left ventricular (LV) volume analysis in patients with cardiomyopathy and distorted LV geometry. METHODS: A total of 53 patients in sinus rhythm with various types of cardiomyopathy (mean age 56 +/- 11 years, 28 men) and adequate 2-dimensional image quality were included. The real-time 3-dimensional echocardiographic multiplane interpolation (MI) and full volume reconstruction (FVR) methods were used for LV volume analysis. Magnetic resonance imaging was used as the reference method. RESULTS: A strong correlation (R(2) > 0.95) was found for all LV volume and ejection fraction measurements by either real-time 3-dimensional echocardiographic method. Analysis time was shorter with the FVR method (6 +/- 2 vs 15 +/- 4 minutes, P < .01) as compared with the MI method. Bland-Altman analysis showed greater underestimation of end-diastolic and end-systolic volumes by MI compared with FVR. For the MI method a bias of -24.0 mL (-15.0% of the mean) for end-diastolic volume and -11.3 mL (-18.0% of the mean) for end-systolic volume was found. For FVR analysis these values were -9.9 mL (-6.0% of the mean) and -5.0 mL (-9.0% of the mean), respectively. Ejection fraction was similar for the MI and FVR method with a mean difference compared with magnetic resonance imaging of 0.6 (1.0%) and 0.8 (1.3%), respectively. CONCLUSION: In patients with cardiomyopathy, distorted LV geometry, and good 2-dimensional image quality, the FVR method is faster and more accurate than the MI method in assessment of LV volumes.

Published 3 September 2007 in J Am Soc Echocardiogr, 20(9): 1042-9.
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