Ultrasound Research Today is a free monthly online journal that collates and summarizes the latest research about Ultrasound, including details on screening, diagnosis, pregnancy, detection.

Too late prenatal diagnosis of fetal toxoplasmosis: a case report.

Nowakowska D, Respondek-Liberska M, Golab E, Stray-Pedersen B, Szaflik K, Dzbenski TH, Wilczynski J

Department of Fetal Maternal Medicine, Research Institute Polish Mother's Memorial Hospital, Lodz, Poland. dnowakowska@hotmail.com

OBJECTIVE: We describe a case of severe fetal hydrocephalus due to toxoplasmosis which could not be diagnosed until late gestational age due to the lack of a serologic surveillance program during pregnancy; moreover, this case points to the usefulness of molecular biology tools in the diagnostic process. Abnormal ultrasound in the 2nd trimester was noticed and Toxoplasma gondii was demonstrated in amniotic fluid at the 28th week of gestation both by PCR and by mice inoculation. Fansidar and folinic acid were administered. The newborn suffered from progressive hydrocephalus, seizures, and pathological muscular tonus; ultrasound examination showed massive cerebral calcifications. Ophthalmologic examination revealed bilateral choroidoretinitis. Congenital toxoplasmosis was confirmed by the detection of anti- T. gondii IgM and IgA in the neonatal serum. CONCLUSION: The presented case is an example of severe fetal toxoplasmosis diagnosed and treated in utero.

Published 12 April 2005 in Fetal Diagn Ther, 20(3): 190-3.
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